From the APS Journal Archive: Mechanisms of Gene-Environment Interaction Effects in the Development of Conduct Disorder

‘Mechanisms of Gene-Environment Interaction Effects in the Development of Conduct Disorder’ by Kenneth A. Dodge1 was published in Perspectives on Psychological Science in July 2009 and has been cited 11 times (via Web of Science) since publication.

Click here to read the article in full.

Abstract:

The gene—environment interaction effect in the development of conduct disorder is one of the most important discoveries of the past decade, but the mechanisms through which this effect operates remain elusive. I propose a model of these processes that focuses on the individual’s response to a threatening stimulus in ongoing social interaction. The individual’s response coordinates three interrelated systems: neural, autonomic, and information-processing. In each system, adaptive, evolutionarily selected response patterns characterize normal responding, but in psychopathology these patterns have gone awry. Antecedents of individual differences in these response patterns arise from genetic polymorphisms, adverse environmental experiences early in life, and their interaction. Programs of research are proposed to test hypotheses in the model through longitudinal, experimental, and clinical intervention methods. This model can serve as a template for inquiry in other forms of developmental psychopathology.

1Duke University

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